Tolerance of Skin Grafts to Radiation

Tolerance of rat skin grafts in adult mice.

Adult CBA mice may be made tolerant of August rat tail skin grafts by short intensive treatments with antilymphocyte serum followed by massive ( approximately 100 x 10(6) cells) injections of August rat lymphoid cells. Prolonged tolerance can be achieved only in thymectomized mice, and is accompanied by lymphoid cell chimerism and the manufacture of rat protein. The rat lymphoid cell donors mus...

History of Skin Grafts

Cryopreservation of Skin Tissues for Skin Grafts

Preservation of living tissue and organs are very important to ensure successful transplantation. The storage of living tissue, from the time of removal of the donor tissue until transplantation, is one of the most important factors for successful tissue transplantation. The purpose of living tissue storage is to maintain the viability of the mammalian cells, and various methods have been devel...

Bioengineered Self-assembled Skin as an Alternative to Skin Grafts

For patients with extensive burns or donor site scarring, the limited availability of autologous and the inevitable rejection of allogeneic skin drive the need for new alternatives. Existing engineered biologic and synthetic skin analogs serve as temporary coverage until sufficient autologous skin is available. Here we report successful engraftment of a self-assembled bilayered skin construct d...

Preputial Skin Grafts

Although skin grafting originated 2500 to 3000 years ago, it was until the 19 th century that this technique was again introduced as a reconstructive option. While 19th century surgeons used grafts to repair their most difficult cases, skin grafting has since evolved into a modality that is routinely and sometimes preferentially used for the surgical repair of skin defects [1]. In this chapter ...